Jakóbiec T, Stankiewicz J, Dobek R, Zawisza T
Arch Immunol Ther Exp (Warsz). 1978;26(1-6):935-41.
In the course of studies on compounds with expected antiinflammatory and immunosuppressive action a number of new derivatives of 2-amino-4-p-chlorophenylthiazole-s-acetic acid have been synthetized. The chemical structure of these compounds has been confirmed by elemental analysis and IR spectra. The newly obtained compounds were investigated pharmacologically. It has been found that some of the derivatives possess antiinflammatory and immunosuppressive activity.
在对具有预期抗炎和免疫抑制作用的化合物的研究过程中,合成了多种2-氨基-4-对氯苯基噻唑-5-乙酸的新衍生物。这些化合物的化学结构已通过元素分析和红外光谱得以证实。对新得到的化合物进行了药理研究。结果发现,其中一些衍生物具有抗炎和免疫抑制活性。