Ford M J, Camilleri M, Zinsmeister A R, Hanson R B
Gastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota, USA.
Gastroenterology. 1995 Dec;109(6):1772-80. doi: 10.1016/0016-5085(95)90743-2.
BACKGROUND & AIMS: Psychosensory stimulation increases the perception of stimuli in different regions of the human colon. The aim of this study was to determine the perception of pain and gas during distention of two colonic regions in healthy volunteers during stress and relaxation.
In 22 healthy subjects, phasic distentions of transverse and sigmoid colon were performed using infinitely compliant balloons, and symptoms were measured before and during one of three randomized treatments: sham or active relaxation or mental stress. Anxiety ratings and somatic cold-pain sensitivity were included in a multivariate regression model.
Mental stress increased levels of anxiety (P < 0.05) and the sensation of gas (P < 0.01), but not pain (P = NS), during transverse colon distentions and the sensations of gas and pain during sigmoid distentions (P < 0.05). Active relaxation reduced only sensation of gas in the sigmoid colon. Somatic pain sensitivity and pretreatment colonic sensory scores were significantly associated with the sensory scores during treatments.
Psychosensory stimulation increases colonic sensation during short-term distention in two regions of the human colon; relaxation alone exerts a smaller influence on sensations arising in the sigmoid colon.
心理感觉刺激可增强人类结肠不同区域对刺激的感知。本研究旨在确定健康志愿者在应激和放松状态下，两个结肠区域扩张时的疼痛和气体感知情况。
对22名健康受试者，使用无限顺应性球囊对横结肠和乙状结肠进行阶段性扩张，并在三种随机治疗之一（假治疗、主动放松或心理应激）之前和期间测量症状。焦虑评分和躯体冷痛敏感性纳入多变量回归模型。
在横结肠扩张期间，心理应激增加了焦虑水平（P < 0.05）和气体感觉（P < 0.01），但未增加疼痛（P = 无显著性差异）；在乙状结肠扩张期间，增加了气体和疼痛感觉（P < 0.05）。主动放松仅降低了乙状结肠中的气体感觉。躯体疼痛敏感性和治疗前结肠感觉评分与治疗期间的感觉评分显著相关。
心理感觉刺激在人类结肠两个区域短期扩张期间增加结肠感觉；单独放松对乙状结肠产生的感觉影响较小。
