Ford M J, Camilleri M, Wiste J A, Hanson R B
Gastroenterology Research Unit, Mayo Clinic, Rochester, MN 55905, USA.
Gut. 1995 Aug;37(2):264-9. doi: 10.1136/gut.37.2.264.
It is not yet clear whether the regional differences in the physical properties of the colon influence its motor responses. Tonic and phasic colonic motility and compliance of the transverse and sigmoid colon were therefore assessed using a combined barostat-manometry assembly in 22 healthy subjects. Measured colonic compliance was corrected by subtraction of the compliance of the closed barostat system. The mean (SEM) preprandial colonic volumes in the transverse and sigmoid colon were similar (150 (12) and 128 (13) ml, p = NS), corresponding to calculated mean (SEM) colonic diameters of 4.3 cm and 4.0 cm respectively. The mean increase in colonic tone postprandially was significantly greater in the transverse (24.1% (3.5)) than in the sigmoid colon (13.1% (3.0), p < 0.01). The mean increase in phasic contractility was significantly greater, however, in the sigmoid than in the transverse colon (1270 (210) and 425 (60) mm Hg/90 min respectively, p < 0.01). Compliance was greater in the transverse than sigmoid colon (7.6 (0.44) and 4.1 (0.15) ml/mm Hg, p < 0.001). The fasting volume of the colon was significantly correlated with the magnitude of the tonic response to the meal in the transverse and sigmoid colon (p < 0.001 for both). In conclusion, there are quantitatively different but qualitatively similar phasic and tonic responses to the meal in the two colonic regions. Differences in the viscoelastic and luminal dimensions may partly account for these differences in tonic responses.
结肠物理特性的区域差异是否会影响其运动反应尚不清楚。因此，我们使用联合压力传感器-测压装置对22名健康受试者的横结肠和乙状结肠的张力性和阶段性结肠运动及顺应性进行了评估。通过减去封闭压力传感器系统的顺应性来校正测量的结肠顺应性。横结肠和乙状结肠餐前的平均（标准误）结肠容积相似（分别为150（12）和128（13）ml，p = 无显著性差异），分别对应计算得出的平均（标准误）结肠直径为4.3 cm和4.0 cm。餐后横结肠张力的平均增加显著大于乙状结肠（分别为24.1%（3.5）和13.1%（3.0），p < 0.01）。然而，乙状结肠阶段性收缩力的平均增加显著大于横结肠（分别为1270（210）和425（60）mmHg/90分钟，p < 0.01）。横结肠的顺应性大于乙状结肠（分别为7.6（0.44）和4.1（0.15）ml/mmHg，p < 0.001）。结肠的空腹容积与横结肠和乙状结肠对进餐的张力反应幅度显著相关（两者p均< 0.001）。总之，两个结肠区域对进餐的阶段性和张力性反应在数量上不同但质量上相似。粘弹性和管腔尺寸的差异可能部分解释了这些张力反应的差异。
