Sterzik K, Strehler E, De Santo M, Trumpp N, Abt M, Rosenbusch B, Kreienberg R
Abt. Frauenheilkunde und Geburtshilfe, Universität Ulm.
Geburtshilfe Frauenheilkd. 1995 Sep;55(9):532-5. doi: 10.1055/s-2007-1022833.
The aim of this study was to investigate the relation between cigarette smoking of women and the fertilisation and pregnancy rates obtained by in-vitro fertilisation treatment. To guarantee an objective recording of tobacco smoke exposure, the smoking habit was not determined by questionnaires, but by cotinine, the principal metabolite of nicotine. The study population consisted of 197 women (23-39 years old) who were divided into the groups 'non-smokers' (n = 68), 'passive smokers' (n = 26) and 'active smokers' (n = 103) according to the cotinine concentration measured in follicular fluid. The reason for infertility was strictly a tubal factor with apparently normal ovulatory cycles. There were no significant differences in fertilisation and pregnancy rates between the different groups (p > 0.05). The E2 serum levels were significantly decreased in women who smoked, compared with the results obtained from non-smokers and passive smokers (p < 0.025). Overall, a strong negative correlation of the cotinine- and E2 levels was observed (r = -0.65). The results suggest that there is no clinically detectable impairment of fertilisation potential due to female smoking and that there is a greater influence on the outcome of in-vitro fertilisation by other factors.
本研究的目的是调查女性吸烟与体外受精治疗的受精率和妊娠率之间的关系。为确保客观记录烟草烟雾暴露情况，吸烟习惯并非通过问卷调查确定，而是通过尼古丁的主要代谢物可替宁来确定。研究人群包括197名年龄在23至39岁之间的女性，根据卵泡液中测得的可替宁浓度，她们被分为“非吸烟者”组（n = 68）、“被动吸烟者”组（n = 26）和“主动吸烟者”组（n = 103）。不孕原因严格为输卵管因素，排卵周期明显正常。不同组之间的受精率和妊娠率无显著差异（p > 0.05）。与非吸烟者和被动吸烟者的结果相比，吸烟女性的血清E2水平显著降低（p < 0.025）。总体而言，观察到可替宁水平与E2水平呈强负相关（r = -0.65）。结果表明，女性吸烟在临床上未检测到对受精潜力的损害，且其他因素对体外受精结果的影响更大。
