白细胞介素-1β对迷走神经至胸腺传出活动的影响。

The effect of interleukin-1 beta on the efferent activity of the vagus nerve to the thymus.

作者信息

Niijima A, Hori T, Katafuchi T, Ichijo T

机构信息

Department of Physiology, Niigata University School of Medicine, Japan.

出版信息

J Auton Nerv Syst. 1995 Aug 4;54(2):137-44. doi: 10.1016/0165-1838(95)00003-g.

DOI:10.1016/0165-1838(95)00003-g

PMID:7499725

Abstract

The effects of intravenous (i.v.) administration of recombinant human interleukin-1 beta (rhIL-1 beta) and human interleukin-1 beta-fraction (hfrIL-1 beta) on the activity of vagal efferent fibers innervating the thymus were observed in urethane-anesthetized rats. An i.v. injection of 10 ng rhIL-1 beta or hfrIL-1 beta caused a similar degree of increase in the efferent activity, which lasted longer than 2 h. The least effective dose was 1 ng and dose-dependent responses were observed after i.v. injection of rhIL-1 beta at doses of 1 ng, 10 ng and 100 ng. The IL-1 beta-induced activation of efferent activity of the vagal branch to the thymus implicates their involvement in the neural modulation of the thymic function.

摘要

在乌拉坦麻醉的大鼠中，观察了静脉注射重组人白细胞介素-1β（rhIL-1β）和人白细胞介素-1β组分（hfrIL-1β）对支配胸腺的迷走神经传出纤维活性的影响。静脉注射10 ng rhIL-1β或hfrIL-1β引起的传出活性增加程度相似，持续时间超过2小时。最小有效剂量为1 ng，静脉注射1 ng、10 ng和100 ng剂量的rhIL-1β后观察到剂量依赖性反应。IL-1β诱导的迷走神经分支至胸腺的传出活性激活表明它们参与了胸腺功能的神经调节。