Lécuru F, Taurelle R, Bernard J P, Vildé F
Service de Gynécologie Obstétrique, Hôpital Boucicaut, Paris.
J Gynecol Obstet Biol Reprod (Paris). 1995;24(5):482-4.
A second tubal pregnancy occurred in the same tube as the first one which had been treated with methotrexate injection. The hysterosalpingogram performed 3 months after the methotrexate injection was normal. The recurrent tubal pregnancy was treated by laparoscopic salpingectomy. The pathology report confirmed non-ruptured tubal pregnancy. No damage to the tube could be imputed to the methotrexate injection. This observation confirms that methotrexate has no deleterious effect on tubal epithelium but also emphasizes that recurrent ectopic pregnancy can occur despite a patent tube.
第二次输卵管妊娠发生在与首次接受甲氨蝶呤注射治疗的同一侧输卵管。甲氨蝶呤注射3个月后进行的子宫输卵管造影显示正常。复发性输卵管妊娠通过腹腔镜输卵管切除术治疗。病理报告证实为未破裂的输卵管妊娠。甲氨蝶呤注射未对输卵管造成损害。该观察结果证实甲氨蝶呤对输卵管上皮无有害影响，但也强调尽管输卵管通畅，仍可能发生复发性异位妊娠。
