Lagorio S, Forastiere F, Rapiti E, Di Pietro A, Costa G
Istituto Superiore di Sanità, Laboratorio Igiene Ambientale, Roma.
Med Lav. 1995 Jul-Aug;86(4):309-24.
In the framework of occupational disease surveillance program, based on integration of current information systems, the first Italian occupational mortality study was carried out. This paper reports on excess lung cancer risk by industry and occupation. The study population consists of subjects included in the Italian Cross-Sectional Study (STI) and in the Turin Longitudinal Study (SLT), both of which are surveys based on record-linkage procedures between census records and death certificates. The STI is a six-month follow-up of Italian residents at the 1981 census. The SLT is a prospective study of Turin residents at the 1981 census, followed for mortality up to 1989. Only persons aged 18-64 years at entry, and economically active, were eligible for the occupational mortality analysis (i.e. 15,734 deceased individuals out of 13 million subjects in the STI, and 435,608 individuals, among whom 10,789 deaths occurred, in the SLT). Information about job and economic activity recorded at census consisted of the Italian standard 1981 industry and occupation codes. Lung cancer relative risks by category of industry and job were estimated as mortality odds ratios (MOR) in the STI, and as observed to expected death ratios (SMR) in the SLT. Only excess risks based on > or = 3 observed cases and with p < 0.1, were included in the present report. Lung cancer mortality was increased in different industries and jobs. The excess risks found in the mechanic and transport industries are of particular interest in a public health perspective, due to the high number of Italian workers employed in these sectors. From an etiologic point of view, however, careful attention should be paid to the excess lung cancer risks among workers in the wood manufacturing industry, in meat preparation, and in nursing occupations, where detailed analytical studies of exposure profile and cancer risk are warranted.
在职业病监测项目框架内,基于现有信息系统的整合,开展了意大利首次职业死亡率研究。本文报告了按行业和职业划分的肺癌超额风险。研究人群包括意大利横断面研究(STI)和都灵纵向研究(SLT)中的对象,这两项研究均基于人口普查记录与死亡证明之间的记录链接程序。STI是对1981年人口普查时的意大利居民进行的为期六个月的随访。SLT是对1981年人口普查时的都灵居民进行的前瞻性研究,随访至1989年的死亡率。仅纳入初始年龄在18 - 64岁且从事经济活动的人员进行职业死亡率分析(即STI中1300万对象中有15734名死亡个体,SLT中有435608名个体,其中10789人死亡)。人口普查记录的工作和经济活动信息由1981年意大利标准行业和职业代码组成。按行业和职业类别划分的肺癌相对风险在STI中估计为死亡比数比(MOR),在SLT中估计为观察到的与预期死亡比(SMR)。本报告仅纳入基于≥3例观察病例且p < 0.1的超额风险。不同行业和职业的肺癌死亡率有所增加。从公共卫生角度来看,机械和运输行业发现的超额风险尤其值得关注,因为这些部门雇佣的意大利工人数量众多。然而,从病因学角度来看,应特别关注木材制造业、肉类加工行业和护理职业的工人中肺癌超额风险,在这些行业有必要对暴露情况和癌症风险进行详细的分析研究。