硫辛酸长期治疗不能在体内预防丙二酸毒性。

Chronic treatment with thioctic acid does not protect against malonate toxicity in vivo.

作者信息

Angel R, Greenamyre J T

机构信息

Department of Neurology, University of Rochester Medical Center, NY 14642, USA.

出版信息

Neurosci Lett. 1995 Aug 18;196(1-2):125-7. doi: 10.1016/0304-3940(95)11863-r.

DOI:10.1016/0304-3940(95)11863-r

PMID:7501239

Abstract

We reported previously that short-term systemic pretreatment with thioctic acid is protective against NMDA and malonate lesions of the striatum. In the current study, we examined the effects of 3 weeks of pretreatment with various doses of thioctic acid (5-60 mg/kg per day) on malonate-induced striatal degeneration in adult rats. In this paradigm, we were unable to demonstrate protection against malonate toxicity. The reasons for the difference in efficacy between subacute and chronic treatment remain to be defined.

摘要

我们之前报道过，硫辛酸进行短期全身预处理可保护纹状体免受N-甲基-D-天冬氨酸（NMDA）和丙二酸损伤。在当前研究中，我们检测了用不同剂量硫辛酸（每天5 - 60毫克/千克）进行3周预处理对成年大鼠丙二酸诱导的纹状体变性的影响。在这个实验模式中，我们未能证明其对丙二酸毒性具有保护作用。亚急性和慢性治疗疗效差异的原因仍有待确定。