Zhu Y S, Franklin S O, Inturrisi C E
Department of Pharmacology, Cornell University Medical College, New York, NY 10021, USA.
Neurosci Lett. 1995 Aug 25;196(3):197-200. doi: 10.1016/0304-3940(95)11877-y.
Metrazole (MTZ) induces sequential activation of c-fos, proenkephalin (Penk) and tyrosine hydroxylase (TH) gene expression in the rat adrenal and c-fos and Penk gene expression in the rat hippocampus. As in the rat, MTZ produced a dose-dependent induction of c-fos mRNA in the hamster adrenal and hippocampus together with an increase in adrenal TH mRNA. Although MTZ-induction of preproenkephalin (PPenk) mRNA was observed in the hippocampus of the hamster, the same treatment failed to induce PPenk mRNA in the hamster adrenal. These results indicate that Penk gene expression in the hamster is differentially regulated in the adrenal and hippocampus. Furthermore, the regulation of adrenal Penk gene expression differs significantly when rat and hamster are compared.
甲磺酸麦角乙脲（MTZ）可诱导大鼠肾上腺中c-fos、前脑啡肽原（Penk）和酪氨酸羟化酶（TH）基因表达的顺序激活，以及大鼠海马中c-fos和Penk基因表达的顺序激活。与大鼠一样，MTZ在仓鼠肾上腺和海马中产生剂量依赖性的c-fos mRNA诱导，并伴有肾上腺TH mRNA的增加。虽然在仓鼠海马中观察到MTZ诱导前脑啡肽原（PPenk）mRNA，但相同处理未能在仓鼠肾上腺中诱导PPenk mRNA。这些结果表明，仓鼠中Penk基因表达在肾上腺和海马中受到不同调节。此外，比较大鼠和仓鼠时，肾上腺Penk基因表达的调节存在显著差异。
