[原位肝移植实验中止血障碍的研究]

[Disorders of hemostasis in orthotopic liver transplantation in an experiment].

作者信息

Dement'eva I I, Andrianova M Iu, Paliulina M V, Broun N K, Zhidkov I L, Gom'e S V

出版信息

Patol Fiziol Eksp Ter. 1995 Jul-Sep(3):23-6.

Abstract

The study was undertaken to examine blood coagulative parameters in experimental orthotopic liver grafting. Plasma hemostatic parameters were studied in animals undergone successful and unsuccessful surgery. The preservation of a graft, anesthetization, and blood-substitute therapy were found to substantially affect the severity of hemostatic disorders. The liver-free period was characterized by changes in the fibrinolytic system and the activity of a plasma coagulation, by enhanced hypocoagulation, and thrombocytopenia. The findings suggest that timely correction of blood coagulative disorders is highly essential in orthotopic liver grafting. Prevention and prompt correction of hypocoagulation and thrombocytopenia are the most urgent.

摘要

本研究旨在检测实验性原位肝移植中的血液凝固参数。对手术成功和失败的动物的血浆止血参数进行了研究。发现移植物的保存、麻醉和血液替代疗法会对止血障碍的严重程度产生重大影响。无肝期的特征是纤溶系统和血浆凝固活性发生变化、低凝增强和血小板减少。研究结果表明，原位肝移植中及时纠正血液凝固障碍至关重要。预防并迅速纠正低凝和血小板减少最为紧迫。