Kogan A Kh, Bolevich S, Daniliak I G
Patol Fiziol Eksp Ter. 1995 Jul-Sep(3):34-40.
The study was conducted by using leukocytes isolated from 74 apparently healthy donors and 60 patients with bronchial asthma. The generation of active oxygen forms was determined by luminolo- and lucigenin-dependent chemiluminescence techniques and NTC-reaction. The findings suggest that at the tension close to the blood tension of 37.5 mm Hg and the high tension of 146 mm Hg is a powerful natural inhibitor of leukocytic generation of active oxygen forms. At an exacerbation, the inhibitory effect of carbon dioxide on the leukocytic generation of active oxygen forms decreased in most (70%) patients with bronchial asthma, which potentiates the free radical mechanism of development of bronchial asthma. It may be held that the literature-described use of carbon dioxide for the treatment of bronchial asthma is justifiable only in a lower proportion of patients who have preserved a high sensitivity to the inhibitory effect of carbon dioxide on the generation of active oxygen forms.
该研究使用从74名表面健康的供体和60名支气管哮喘患者中分离出的白细胞进行。通过鲁米诺和光泽精依赖性化学发光技术以及NTC反应来测定活性氧形式的产生。研究结果表明，在接近37.5 mmHg的血压张力和146 mmHg的高张力下，二氧化碳是白细胞活性氧形式产生的一种强大天然抑制剂。在病情加重时，大多数（70%）支气管哮喘患者中二氧化碳对白细胞活性氧形式产生的抑制作用降低，这增强了支气管哮喘发展的自由基机制。可以认为，文献中描述的使用二氧化碳治疗支气管哮喘仅在较低比例的对二氧化碳对活性氧形式产生的抑制作用仍保持高敏感性的患者中是合理的。
