人类结构转录因子HMGI-C的基因由五个外显子组成，每个外显子编码一个独特的功能元件。
The gene for the human architectural transcription factor HMGI-C consists of five exons each coding for a distinct functional element.
作者信息
Chau K Y, Patel U A, Lee K L, Lam H Y, Crane-Robinson C
机构信息
Biophysics Laboratories, University of Portsmouth, UK.
出版信息
Nucleic Acids Res. 1995 Nov 11;23(21):4262-6. doi: 10.1093/nar/23.21.4262.
Abstract
The gene on chromosome 12 coding for the human protein HMGI-C has been cloned and partially sequenced. It consists of five exons, the first and last of which include long untranslated regions. The 5' UTR includes a (CA/T)n tract and a polymorphic (CT)n tract. Exons II, III and IV (87, 51 and 33 bp) are dispersed over > 30 kb. Exons I-III separately encode the three basic DNA binding domains ('A-T hooks'), exon IV encodes an 11 amino acid sequence characteristic of HMGI-C and absent from the human HMGI(Y) gene [Friedmann, M., Holth, L. T., Zoghbi, H. Y. and Reeves, R. (1993) Nucleic Acids Res., 21, 4259-4267], whilst exon V encodes the acidic C-terminal domain, which is subject to multiple phosphorylation. The HMGI-C gene is thus a striking example of the separation of functional protein elements into different coding exons.
摘要
位于12号染色体上编码人类蛋白质HMGI-C的基因已被克隆并进行了部分测序。它由五个外显子组成，其中第一个和最后一个外显子包含长的非翻译区。5'非翻译区包含一个(CA/T)n序列和一个多态性(CT)n序列。外显子II、III和IV（分别为87、51和33 bp）分散在超过30 kb的区域。外显子I - III分别编码三个基本的DNA结合结构域（“A - T钩”），外显子IV编码HMGI-C特有的11个氨基酸序列，而人类HMGI(Y)基因中不存在该序列[Friedmann, M., Holth, L. T., Zoghbi, H. Y.和Reeves, R. (1993) Nucleic Acids Res., 21, 4259 - 4267]，外显子V编码酸性的C末端结构域，该结构域会发生多次磷酸化。因此，HMGI-C基因是一个将功能性蛋白质元件分隔到不同编码外显子中的显著例子。
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