Yossif A M, Ibrahim T M, Salem H A, Gamil N M, el-Sayed L M
Rheumatology Unit, Benha Teaching Hospital, Egypt.
Pharmacology. 1995 Sep;51(3):160-4. doi: 10.1159/000139330.
Male albino rats were fed a high lipid diet for 5 consecutive weeks. We studied the development of paw inflammation after an injection with Freund's complete adjuvant. Increasing the lipid content of the diet significantly increased the rate of paw inflammation. Also the effect on this process of oral administration of a xanthine oxidase inhibitor (allopurinol, 50 mg/kg) for 15 consecutive days was studied. Results indicated that inflammation was significantly inhibited by allopurinol.
雄性白化病大鼠连续5周喂食高脂饮食。我们研究了注射弗氏完全佐剂后爪部炎症的发展情况。增加饮食中的脂质含量显著提高了爪部炎症的发生率。此外，还研究了连续15天口服黄嘌呤氧化酶抑制剂（别嘌呤醇，50毫克/千克）对这一过程的影响。结果表明，别嘌呤醇可显著抑制炎症。
