Reist C, Helmeste D, Katz M, Vu R, Albers L, Tang S W
Psychiatry Service, Long Beach Veterans Affairs Medical Center, CA 90822, USA.
Psychiatry Res. 1995 Aug 28;57(3):275-8. doi: 10.1016/0165-1781(95)02716-a.
Numerous lines of evidence have suggested a key role for serotonin (5-hydroxytryptamine, 5HT) pathways in the regulation of alcohol consumption. To explore the functioning of the 5HT2 receptor in alcoholism, 5HT-stimulated intracellular calcium response was measured in platelets from abstinent alcoholic patients and normal comparison subjects. No difference in resting or stimulated calcium levels was observed. This finding suggests that 5HT2 receptor function is unaffected in non-drinking alcoholic subjects. The previously reported 5HT inhibition in actively drinking alcoholic subjects is likely to be a state rather than trait marker of alcoholism.
大量证据表明血清素（5-羟色胺，5HT）通路在酒精摄入调节中起关键作用。为了探究5HT2受体在酒精中毒中的功能，对戒酒的酒精中毒患者和正常对照者的血小板中5HT刺激的细胞内钙反应进行了测量。未观察到静息钙水平或刺激后钙水平的差异。这一发现表明，在不饮酒的酒精中毒受试者中，5HT2受体功能未受影响。先前报道的在正在饮酒的酒精中毒受试者中5HT受到抑制，这可能是酒精中毒的一种状态而非特质标记。
