Hibberd P L, Surman O S, Bass M, Tolkoff-Rubin N E, Cosimi A B, Schooley R T, Doran M, Delvecchio A, Rosal M, Rubin R
Department of Medicine, Massachusetts General Hospital, Boston, USA.
Psychosomatics. 1995 Nov-Dec;36(6):561-3. doi: 10.1016/S0033-3182(95)71612-7.
Although cytomegalovirus (CMV) is rarely cultured from peripheral-blood leukocytes of immunocompetent patients, it may be cultured from up to 60% of renal transplant recipients, 1 to 4 months after transplantation. During this same period, renal transplant recipients are often referred for psychiatric evaluation. Since CMV may infect the central nervous system, the relationship between isolation of CMV from peripheral-blood leukocytes (viremia) and psychiatric evaluation was investigated in 80 renal allograft recipients at the Massachusetts General Hospital. Five of 16 (31%) patients with viremia and 7 of 64 (11%) patients without viremia required psychiatric consultation (P = 0.04, two-tailed Fisher exact test). CMV viremia may be an important but treatable contributor to psychiatric symptoms in the transplant recipient.
虽然巨细胞病毒（CMV）很少能从免疫功能正常患者的外周血白细胞中培养出来，但在肾移植受者移植后1至4个月，高达60%的患者可能培养出该病毒。在同一时期，肾移植受者经常被转介进行精神科评估。由于CMV可能感染中枢神经系统，因此在马萨诸塞州总医院，对80例肾移植受者外周血白细胞中CMV分离（病毒血症）与精神科评估之间的关系进行了研究。16例病毒血症患者中有5例（31%）、64例无病毒血症患者中有7例（11%）需要精神科会诊（P = 0.04，双侧Fisher精确检验）。CMV病毒血症可能是移植受者精神症状的一个重要但可治疗的因素。
