Dionisio D, Sterrantino G, Meli M, Trotta M, Milo D, Leoncini F
Divisione di Malattie Infettive, Ospedale di Careggi, Firenze.
Recenti Prog Med. 1995 Oct;86(10):394-7.
The efficacy of furazolidone for treatment of intestinal microsporidiosis due to Enterocytozoon bieneusi was studied in three patients with AIDS. All patients had chronic diarrhoea and weight loss. Mean CD4 cell count was 34.6/mm3. A course of furazolidone (100 mg orally four times a day) was given for 20 days. The drug was well tolerated and neither side effects nor alterations in the laboratory parameters were noted. Diarrhoea ceased within a mean of 12 days of starting treatment and clearance of microsporidian shedding in stool was observed. In one of the patients, however, symptomatic microsporidiosis recurred. Therefore furazolidone seems to have a transient but significant effect on intestinal infection due to Enterocytozoon bieneusi.
研究了呋喃唑酮对3例艾滋病患者肠道毕氏肠微孢子虫病的治疗效果。所有患者均有慢性腹泻和体重减轻。平均CD4细胞计数为34.6/mm³。给予一个疗程的呋喃唑酮（每日4次口服100mg），持续20天。该药物耐受性良好，未观察到副作用或实验室指标的改变。腹泻在开始治疗后平均12天内停止，且观察到粪便中微孢子虫脱落消失。然而，其中1例患者出现了有症状的微孢子虫病复发。因此，呋喃唑酮似乎对毕氏肠微孢子虫引起的肠道感染有短暂但显著的疗效。
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