99m锝-二乙基-对氨基马尿酸：对其结构研究的一项贡献
99mTc-diethyl-HIDA: a contribution to the study of its structure.
作者信息
Fonda U, Pedersen B
出版信息
Eur J Nucl Med. 1978 Apr 1;3(2):87-9. doi: 10.1007/BF00251629.
Sephadex column chromatography has shown that 99mTc-diethyl-HIDA consists of two clearly separable components. One of them seems to be an intermediate compound changing into the other, almost completely within two hours after reconstitution of the diethyl-HIDA (Solco HIDA) with pertechnetate. The two components could be the mono- and biscomplex of N-(2,6-diethyl-acetanilid)-imino diacetic acid with one atom of technetium. Animal experiments show that there is no important difference in the biological distribution in mice between the two components.
葡聚糖凝胶柱色谱法表明，99mTc - 二乙基亚氨基二乙酸（HIDA）由两个可清晰分离的组分组成。其中一个似乎是一种中间化合物，在用高锝酸盐复溶二乙基亚氨基二乙酸（索尔科HIDA）后两小时内几乎完全转变成另一种化合物。这两种组分可能是N -（2,6 - 二乙基乙酰苯胺基）亚氨基二乙酸与一个锝原子形成的单络合物和双络合物。动物实验表明，这两种组分在小鼠体内的生物分布没有重要差异。
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