两例急性髓性白血病患者中粒细胞集落刺激因子诱发的皮肤疹

Cutaneous eruptions induced by granulocyte colony-stimulating factor in two cases of acute myelogenous leukemia.

作者信息

Yamashita N, Natsuaki M, Morita H, Kitano Y, Sagami S

机构信息

Department of Dermatology, Hyogo College of Medicine, Japan.

出版信息

J Dermatol. 1993 Aug;20(8):473-7. doi: 10.1111/j.1346-8138.1993.tb01323.x.

DOI:10.1111/j.1346-8138.1993.tb01323.x

PMID:7504005

Abstract

Recombinant human granulocyte colony-stimulating factor (rhG-CSF) induced cutaneous eruptions in two cases of acute myelogenous leukemia. In both cases, the eruptions appeared during rhG-CSF therapy for neutropenia induced by the remission-induction chemotherapy and disappeared rapidly after the discontinuance of rhG-CSF therapy. Histopathology of those eruptions revealed dermal cell infiltrations consisting of some neutrophils and atypical cells. It was interesting that, although there were no leukemic cells in the peripheral blood or bone marrow, eruptions containing many leukemic cells appeared. The mechanism of the appearance of these eruptions was unclear, but it was considered that a few leukemic cells might have responded to rhG-CSF and proliferated in the skin.

摘要

重组人粒细胞集落刺激因子（rhG-CSF）在两例急性髓性白血病患者中诱发了皮肤疹。在这两例患者中，皮疹均出现在rhG-CSF治疗因诱导缓解化疗引起的中性粒细胞减少期间，在rhG-CSF治疗停止后迅速消失。这些皮疹的组织病理学显示真皮细胞浸润，由一些中性粒细胞和非典型细胞组成。有趣的是，尽管外周血或骨髓中没有白血病细胞，但出现了含有许多白血病细胞的皮疹。这些皮疹出现的机制尚不清楚，但据认为可能有少数白血病细胞对rhG-CSF产生反应并在皮肤中增殖。