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用重组人粒细胞集落刺激因子（rhG-CSF）治疗费尔蒂综合征，出现关节炎发作和皮疹。

Felty's syndrome treated with rhG-CSF associated with flare of arthritis and skin rash.

作者信息

McMullin M F, Finch M B

机构信息

Queen's University of Belfast.

出版信息

Clin Rheumatol. 1995 Mar;14(2):204-8. doi: 10.1007/BF02214945.

DOI:10.1007/BF02214945
PMID:7540527
Abstract

A patient with Felty's syndrome and rheumatoid arthritis was treated with recombinant granulocyte stimulating factor rhG-CSF (Neupogen) in view of severe neutropenia. He had a prompt rise in his neutrophil count and associated with this a severe flare of his arthritis and a skin rash. rhG-CSF was stopped, his neutrophil count fell rapidly and his symptoms resolved. rhG-CSF and the resulting rise in neutrophil count may be associated with flare of autoimmune disease in susceptible individuals.

摘要

一名患有费尔蒂综合征和类风湿性关节炎的患者，鉴于严重的中性粒细胞减少，接受了重组粒细胞刺激因子rhG-CSF（优保津）治疗。他的中性粒细胞计数迅速上升，与此同时，关节炎严重发作并出现皮疹。停用rhG-CSF后，他的中性粒细胞计数迅速下降，症状也随之缓解。rhG-CSF以及由此导致的中性粒细胞计数升高，可能与易感个体自身免疫性疾病的发作有关。

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2
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Prospective evaluation of the chemiluminescence test for the detection of granulocyte antibodies: comparison with the granulocyte immunofluorescence test.用于检测粒细胞抗体的化学发光试验的前瞻性评估：与粒细胞免疫荧光试验的比较。
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Improvement of pneumonia and arthritis in Felty's syndrome by treatment with granulocyte-macrophage colony-stimulating factor (GM-CSF).粒细胞巨噬细胞集落刺激因子（GM-CSF）治疗费尔蒂综合征的肺炎和关节炎疗效观察
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