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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Indian J Physiol Pharmacol. 1978 Oct-Dec;22(4):347-57.

Intra-atrial injection (right atrium) of pdg in nembutal anaesthetised rats produced bradycardia, hypotension and apnoea followed by hyperpnoea. In very lightly anaesthetised rats, injection of pdg close to the aortic valves produced similar responses and those responses disappeared on maintaining the animals in well-anaesthetised condition. 2. Administration of pdg either into the cerebral circulation or into cerebral ventricles did not produce bradycardia and apnoea. 3. The afferent pathway for these autonomic responses runs in vagus nerve, as shown by experiments before and after bilateral vagotomy. 4. The electrical activity of both expiratory and inspiratory muscles was inhibited during end-expiratory apnoea phase following injection of pdg into the right atrium. 5. Glycine, administered centrally or intravenously, exhibited blockade of pdg induced autonomic responses for more than forty minutes.

在戊巴比妥麻醉的大鼠右心房内注射血小板衍生生长因子（PDG），会导致心动过缓、低血压和呼吸暂停，随后出现呼吸急促。在麻醉非常浅的大鼠中，在主动脉瓣附近注射PDG会产生类似反应，而当动物维持在麻醉良好的状态时，这些反应会消失。2. 将PDG注入脑循环或脑室均不会引起心动过缓和呼吸暂停。3. 如双侧迷走神经切断前后的实验所示，这些自主反应的传入途径走行于迷走神经。4. 向大鼠右心房注射PDG后，在呼气末呼吸暂停阶段，呼气肌和吸气肌的电活动均受到抑制。5. 中枢或静脉给予甘氨酸，可使PDG诱导的自主反应阻断超过40分钟。

Indian J Physiol Pharmacol. 1978 Oct-Dec;22(4):347-57.

Intra-atrial injection (right atrium) of pdg in nembutal anaesthetised rats produced bradycardia, hypotension and apnoea followed by hyperpnoea. In very lightly anaesthetised rats, injection of pdg close to the aortic valves produced similar responses and those responses disappeared on maintaining the animals in well-anaesthetised condition. 2. Administration of pdg either into the cerebral circulation or into cerebral ventricles did not produce bradycardia and apnoea. 3. The afferent pathway for these autonomic responses runs in vagus nerve, as shown by experiments before and after bilateral vagotomy. 4. The electrical activity of both expiratory and inspiratory muscles was inhibited during end-expiratory apnoea phase following injection of pdg into the right atrium. 5. Glycine, administered centrally or intravenously, exhibited blockade of pdg induced autonomic responses for more than forty minutes.

在戊巴比妥麻醉的大鼠右心房内注射血小板衍生生长因子（PDG），会导致心动过缓、低血压和呼吸暂停，随后出现呼吸急促。在麻醉非常浅的大鼠中，在主动脉瓣附近注射PDG会产生类似反应，而当动物维持在麻醉良好的状态时，这些反应会消失。2. 将PDG注入脑循环或脑室均不会引起心动过缓和呼吸暂停。3. 如双侧迷走神经切断前后的实验所示，这些自主反应的传入途径走行于迷走神经。4. 向大鼠右心房注射PDG后，在呼气末呼吸暂停阶段，呼气肌和吸气肌的电活动均受到抑制。5. 中枢或静脉给予甘氨酸，可使PDG诱导的自主反应阻断超过40分钟。