Zelman A, Whittam P, Sullo P, Parsons R, Anzola E, Gisser D
J Dial. 1978;2(5-6):483-93. doi: 10.3109/08860227809080101.
This report concerns the augmentation of peritoneal dialysis using alternating hyper/hypoosmotic peritoneal dialysates, and covers a detailed examination of the longest lived, anephric goat to be maintained using this delivery system. Experimental results show that with this technique: 1) urea clearance can be increased some 200% over control values, 2) the convective transport of urea is unimportant and the increased urea clearance is due primarily to increased peritoneal permeability, 3) net ultrafiltration and electrolyte balance can be easily controlled by variation of total electrolyte and glucose about an appropriate mean. A detailed autopsy failed to demonstrate any gross or microscopic pathology.
本报告涉及使用交替的高渗/低渗腹膜透析液增强腹膜透析，并涵盖了对使用该输送系统维持存活时间最长的无肾山羊的详细检查。实验结果表明，采用该技术：1）尿素清除率可比对照值提高约200%；2）尿素的对流转运并不重要，尿素清除率的提高主要归因于腹膜通透性的增加；3）通过围绕适当均值改变总电解质和葡萄糖含量，可轻松控制净超滤和电解质平衡。详细尸检未发现任何大体或微观病理变化。
