Seki A, Tanaka T, Tomono S, Fujii J
Jpn Heart J. 1978 Nov;19(6):895-903. doi: 10.1536/ihj.19.895.
Ligation of the main femoral artery is followed by a rapid development of collateral arteries. To detect an increase in vascular permeability of the collateral arteries, colloidal carbon (1 ml/Kg, iv) was injected into 153 rabbits at various times after ligation or sham-ligation of the main femoral artery. These animals were killed later and collateral arteries was dissected. Increase in vascular permeability was identified by the presence of visible carbon deposits on the vascular walls. The carbon deposits were frequently found on the intermediate segments of the collateral system in legs with ligation, but were not found on any arteries either in legs with sham-ligation or in contralateral untouched legs. The increase in vascular permeability was observed in 15 of 17 animals as early as 6 hours, in 32 of 36 animals 1 day but only in 5 of 21 animals 6 to 8 days after ligation. The arterial segments with carbon deposits showed various structural changes such as fragmentation of the internal elastic layer, degeneration of the medial muscle and deposition of fibrinoid material. These results indicate that vascular permeability transiently increases in the intermediate segments of developing collateral arteries. Acute vasodilatation may be responsible for the increase in vascular permeability.
结扎股动脉主干后，侧支动脉会迅速发育。为检测侧支动脉血管通透性的增加情况，在结扎或假结扎股动脉主干后的不同时间，向153只兔子静脉注射胶体碳（1毫升/千克）。随后处死这些动物并解剖侧支动脉。通过血管壁上可见的碳沉积来确定血管通透性的增加。在结扎侧的腿部，碳沉积常见于侧支循环系统的中间段，但在假结扎侧的腿部或对侧未处理的腿部的任何动脉中均未发现。早在结扎后6小时，17只动物中有15只观察到血管通透性增加；1天时，36只动物中有32只；但在结扎后6至8天，21只动物中只有5只。有碳沉积的动脉段显示出各种结构变化，如内弹性层断裂、中膜肌肉变性和类纤维蛋白物质沉积。这些结果表明，在发育中的侧支动脉中间段，血管通透性会短暂增加。急性血管扩张可能是血管通透性增加的原因。
