Ketelsen U P, Buchholz G, Schmidt D
Klin Monbl Augenheilkd. 1978 Sep;173(3):317-28.
In 8 patients with chronic progressive ocular muscular dystrophy, of whom some showed a weakness of lid closure, and in 3 normal persons (aged 62 to 69 years) biopsies of the orbicularis oculi muscle were investigated with the light- and electron microscopes. We tried to find out if the histopathological investigation alone of the orbicularis oculi muscle can establish the diagnosis of ocular muscular dystrophy or not. Both groups of investigated persons showed myopathic changes in the orbicularis oculi muscle. These changes were explained as followings of catabiosis (so called "secondary myopathic reaction") in the normal persons. The changes of the patients with myopathies, however, were explained as primarily myopathic, especially with regard to the anomalies of structure, and the pathological inclusions of the mitochondria. The findings showed that there occurred similar histopathological phenomena seen by light microscope in both groups of investigated persons; the muscle cell changes of the myopathy patients, however, were more prominent in the examination of the ultrastructure.
对8例慢性进行性眼肌营养不良患者（其中部分患者表现出闭眼无力）以及3名正常人员（年龄在62至69岁之间）的眼轮匝肌进行了活检，并采用光学显微镜和电子显微镜进行研究。我们试图弄清楚仅通过眼轮匝肌的组织病理学检查能否确诊眼肌营养不良。两组受调查人员的眼轮匝肌均出现了肌病性改变。在正常人员中，这些改变被解释为分解代谢的后续变化（所谓的“继发性肌病反应”）。然而，肌病患者的改变被解释为原发性肌病性改变，特别是在结构异常和线粒体病理包涵体方面。研究结果表明，两组受调查人员在光学显微镜下均出现了相似的组织病理学现象；然而，在超微结构检查中，肌病患者的肌肉细胞变化更为明显。
