Khodzhimatov G M, Movsesov R V, Zhavoronkov N A, Ivanova A G, Zhidkov I L, Sheremet'eva G F, Dement'eva I I, Perel'man M I
Grud Serdechnososudistaia Khir. 1993 Nov-Dec(6):65-70.
Effects of different perfusion conditions and storage of isolated dog lungs on the process of edema development were studied. Sixty-nine mongrel dogs were used in the study. In case of a 15 min perfusion via the pulmonary artery and 12 h storage lung condition depended mainly on the type of solution and addition of protective drugs to this solution. Euro-Collins and low-potassium electrolytic solution markedly increased capillary hydrostatic pressure and drastically reduced plasma colloid-osmotic pressure. As a result filtration coefficient increased and as soon as an hour after reperfusion onset a marked pulmonary edema developed. Use of LPD solution without drugs added for 2.5 h reperfusion was associated with a moderate increase of capillary hydrostatic pressure and negligible decrease of plasma colloid-osmotic pressure. If the reperfusion were longer plasma colloid-osmotic pressure reduced, this leading to development of moderate pulmonary edema. A 15 min lung perfusion via the pulmonary artery and 12 h storage at 1 degree C in LPD solution with membrane protectors and antioxidants was associated with virtually unchanged capillary hydrostatic pressure, plasma colloid-osmotic pressure, and filtration coefficient and, hence, no pulmonary edema.
研究了不同灌注条件及离体犬肺保存对肺水肿形成过程的影响。本研究使用了69只杂种犬。在经肺动脉灌注15分钟及保存12小时的情况下，肺的状况主要取决于溶液类型以及向该溶液中添加的保护药物。Euro - Collins液和低钾电解质溶液显著增加毛细血管流体静压，并大幅降低血浆胶体渗透压。结果滤过系数增加，再灌注开始后一小时内即出现明显的肺水肿。使用未添加药物的LPD溶液进行2.5小时再灌注，毛细血管流体静压有适度增加，而血浆胶体渗透压下降可忽略不计。如果再灌注时间更长，血浆胶体渗透压降低，导致中度肺水肿的发生。经肺动脉对肺进行15分钟灌注，并在含有膜保护剂和抗氧化剂的LPD溶液中于1℃保存12小时，毛细血管流体静压、血浆胶体渗透压和滤过系数实际上未发生变化，因此未出现肺水肿。
