Wildin S R, Landry S H, Zwischenberger J B
Department of Pediatrics, University of Texas Medical Branch, Galveston 77555.
Pediatrics. 1994 Mar;93(3):404-8.
Survivors of venoarterial extracorporeal membrane oxygenation (ECMO) are considered to be at risk for developmental disabilities, but there are few controlled outcome studies. A prospective, controlled study of outcome was performed to quantify the degree and frequency of developmental disabilities in ECMO survivors compared with a matched control group.
From May 1987 through November 1990, 40 of 47 neonates treated with ECMO survived at the University of Texas Medical Branch in Galveston. Longitudinal developmental data were collected, using the Bayley Scales of Infant Development, on 22 ECMO infants and 29 healthy term control infants at 6, 12, and 24 months. Language was assessed at 24 months using the Sequenced Inventory of Communication Development. An additional 13 ECMO infants had developmental data for at least one time point.
Healthy term infants performed significantly better than ECMO infants on the Bayley Scales of Infant Development at 6 and 24 months and on the Sequenced Inventory of Communication Development at 24 months. Mean scores of ECMO infants were well within the average range and 77% of the ECMO infants were developmentally normal.
These data suggest that early developmental morbidity in ECMO survivors is low, considering the severity of their neonatal illness.
静脉-动脉体外膜肺氧合（ECMO）幸存者被认为有发育障碍风险，但对照性结局研究较少。开展了一项前瞻性对照结局研究，以量化ECMO幸存者与匹配对照组相比发育障碍的程度和频率。
1987年5月至1990年11月，得克萨斯大学加尔维斯顿医学分校接受ECMO治疗的47例新生儿中有40例存活。使用贝利婴儿发育量表，收集了22例接受ECMO治疗的婴儿和29例足月健康对照婴儿在6个月、12个月和24个月时的纵向发育数据。在24个月时使用沟通发展序列量表评估语言能力。另有13例接受ECMO治疗的婴儿至少有一个时间点的发育数据。
足月健康婴儿在6个月和24个月时的贝利婴儿发育量表以及24个月时的沟通发展序列量表上的表现明显优于接受ECMO治疗的婴儿。接受ECMO治疗的婴儿的平均得分完全在正常范围内，77%的接受ECMO治疗的婴儿发育正常。
考虑到这些ECMO幸存者新生儿期疾病的严重程度，这些数据表明其早期发育发病率较低。
