Tenascin: does it play a role in epidermal morphogenesis and homeostasis?

Tenascin is a large glycoprotein of the extracellular matrix. Its complex multidomain structure, along with its unique distribution during embryogenesis, inflammation, wound healing, and tumorigenesis suggest this protein may play a significant role in regulating cell proliferation, migration, and differentiation. In this review I will summarize the structural features of tenascin and its localization in skin and discuss some of the potential roles of tenascin in the regulation of keratinocyte biology.