Tveter K J, Otnes B
Urologisk avdeling, Ullevål sykehus, Oslo.
Tidsskr Nor Laegeforen. 1994 Jan 20;114(2):160-2.
Prostate-specific antigen has replaced acid phosphatase as a more sensitive marker of prostatic cancer. It is organ-specific but not cancer-specific. However, high serum level is more often indicative of cancer than of benign hyperplasia. The authors discuss the value of prostate-specific antigen in diagnosis and prognosis, and the indications for its use. This test should be included in the examination of men with prostatic symptoms and in men below age 70-75 with a suspicious finding in the prostate on digital rectal examination. At present, we do not recommend it for screening purposes, except in men with a family history of cancer of the prostate gland.
前列腺特异性抗原已取代酸性磷酸酶，成为前列腺癌更敏感的标志物。它是器官特异性的，但不是癌症特异性的。然而，血清水平升高更常提示癌症而非良性增生。作者讨论了前列腺特异性抗原在诊断和预后方面的价值及其使用指征。对于有前列腺症状的男性以及直肠指检发现前列腺有可疑表现的70 - 75岁以下男性，此项检查应纳入检查项目。目前，我们不推荐将其用于筛查，除非是有前列腺癌家族史的男性。
