抗癌剂。III. 3-氰基-5-（4-吡啶基）吡啶-2-酮的合成及一些化学转化
Cancerostatics. III. Synthesis and some chemical transformations of 3-cyano-5(pyridyl-4.)pyrid-2-one.
作者信息
Nantka-Namirski P, Kaczmarek L
出版信息
Pol J Pharmacol Pharm. 1978 Sep-Oct;30(5):707-12.
PMID:751010
Abstract
In reaction of 3-dimethylamino-2-(pyridyl-4')acrolein with cyanoacetic acid and malononitrile new derivatives of 3,4'-dipyridyl were obtained. The synthesis of pyridyl-4-cyanoacetaldehyde 2 is also described. One of these compounds (8) showed significant cytostatic activity against transplanted Ehrlich ascites carcinoma and Nemeth-Kellner lymphoma.
摘要
在3-二甲基氨基-2-(4'-吡啶基)丙烯醛与氰基乙酸和丙二腈的反应中，得到了3,4'-联吡啶的新衍生物。还描述了4-吡啶基氰基乙醛2的合成。其中一种化合物（8）对移植的艾氏腹水癌和内梅特-凯尔纳淋巴瘤显示出显著的细胞抑制活性。
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