Nazarov P G, Polevshchikov A V
Vestn Ross Akad Med Nauk. 1993 Nov-Dec(9):13-7.
There is evidence that native pentameric C-reactive protein (CRP) and its nonmitogenic monomeric subunits compete with IL 2 at the level of lymphocyte proliferation triggering and block IL 2 receptors due to structural and antigenic similarities between CRP and IL 2. The mechanisms of mitogenic action of CRP and evolutionary bases of the CRP-cytokine system relationship are discussed.
有证据表明，天然五聚体C反应蛋白（CRP）及其无促有丝分裂作用的单体亚基在淋巴细胞增殖触发水平上与白细胞介素2（IL 2）竞争，并由于CRP与IL 2之间的结构和抗原相似性而阻断IL 2受体。本文讨论了CRP的促有丝分裂作用机制以及CRP-细胞因子系统关系的进化基础。
