Fierabracci A, Castagna M, Baschieri L
Cattedra di Clinica Medica 2, Università di Pisa, Italy.
Pathologica. 1993 Sep-Oct;85(1099):467-74.
C cells of the thyroid probably exert a paracrine control on follicular cells through secretion of peptides such as calcitonin and somatostatin. The aim of the present study was to investigate the expression of different peptides produced by C cells in rat thyroid and in the different morphological and pathological conditions of the human thyroid. Therefore we employed the immunohistochemical double-staining method using anti-calcitonin and anti-somatostatin antibodies. The results of this study show the presence of C cells containing calcitonin and C cells containing somatostatin exclusively in the rat and the human thyroid. This distinction with prevalence of one peptide on the other is maintained in the different morphological and pathological conditions of the human thyroid.
甲状腺的C细胞可能通过分泌诸如降钙素和生长抑素等肽类对滤泡细胞发挥旁分泌控制作用。本研究的目的是调查大鼠甲状腺以及人类甲状腺不同形态和病理状况下C细胞所产生的不同肽类的表达情况。因此，我们采用了使用抗降钙素抗体和抗生长抑素抗体的免疫组织化学双重染色方法。本研究结果显示，仅在大鼠和人类甲状腺中存在含降钙素的C细胞和含生长抑素的C细胞。在人类甲状腺的不同形态和病理状况下，一种肽类占优势的这种区别依然存在。
