Suzuki K, Nagao K, Goto M, Uyeda M
Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
J Enzyme Inhib. 1993;7(1):27-32. doi: 10.3109/14756369309020185.
Streptomyces sp. strain No. A-5838 produces three types of inhibitors of DNase II. Two of them, DNI-2 and DNI-3, were distinguished from the previously reported DNase II inhibitors, 5838-DNI and 5923-DNI, by their inhibitory profiles towards phosphodiesterases. DNI-2 has M(r) 654, and is considered to be a coproporphyrin. DNI-3 is an acidic substance with M(r) about 60,000 as estimated by gel filtration. The inhibitory activities of both inhibitors were shown to be temperature-dependent whereas only that of DNI-2 was pH-dependent.
链霉菌属菌株A-5838产生三种脱氧核糖核酸酶II抑制剂。其中两种，DNI-2和DNI-3，通过它们对磷酸二酯酶的抑制谱与先前报道的脱氧核糖核酸酶II抑制剂5838-DNI和5923-DNI区分开来。DNI-2的相对分子质量为654，被认为是粪卟啉。通过凝胶过滤估计，DNI-3是一种相对分子质量约为60000的酸性物质。两种抑制剂的抑制活性均显示出温度依赖性，而只有DNI-2的抑制活性具有pH依赖性。
