Pereira J P, de Souza C P, Mendes N M
Rev Bras Pesqui Med Biol. 1978 Dec;11(6):345-51.
The hexanic extract from the leaves of Euphorbia cotinifolia L. has been experimentally used as molluscicide against Biomphalaria glabrata. The extract was fractionated and the most actives fractions were those of numbers 6 and 7. The lethal concentrations (LC50 and LC90 obtained using fraction 6 against adult snails were 1,2 and 2,4 ppm; for the eggs they were 25,0 and 48,0 ppm. With fraction 7 the lethal concentrations were 1,4 and 3,4 ppm for adult snails; for newly hatched snails they were 4,8 and 8,0 ppm; for the eggs they were 13,0 and 31,0 ppm. In the field the hexanic extract was lethal for the snails in concentrations of 20 ppm in stagnant water. Fractions 6 and 7 were lethal for S. mansoni cercariae and to fish (Lebistes reticulatus) in concentrations below 10 ppm. For mice the extract did not display any toxity in concentrations of 600 mg/kg.
对大戟叶的己烷提取物进行了实验,用作抗光滑双脐螺的杀螺剂。提取物被分馏,活性最高的馏分是6号和7号馏分。用6号馏分对成年蜗牛的致死浓度(LC50和LC90)分别为1.2 ppm和2.4 ppm;对卵的致死浓度分别为25.0 ppm和48.0 ppm。对于7号馏分,成年蜗牛的致死浓度为1.4 ppm和3.4 ppm;对于刚孵化的蜗牛,致死浓度为4.8 ppm和8.0 ppm;对于卵,致死浓度为13.0 ppm和31.0 ppm。在田间,己烷提取物在静水中浓度为20 ppm时对蜗牛具有致死性。6号和7号馏分在浓度低于10 ppm时对曼氏血吸虫尾蚴和鱼类(网纹孔雀鱼)具有致死性。对于小鼠,提取物在浓度为600 mg/kg时未显示任何毒性。