Bohrer M H, Schmoll J
Pathologisches Institut, Fakultät für Klinische Medizin Mannheim, Universität Heidelberg.
Verh Dtsch Ges Pathol. 1993;77:107-10.
102 unselected and untreated prostate carcinomas were immunohistochemically analysed with regard to neuroendocrine (ne) differentiation using a monoclonal antibody against Chromogranin A. Density of ne-tumor cells/mm2 tumor area and arrangement of ne-tumor cells (single cells; small groups and large groups) were determined. We found ne-tumor cells in 90% of all carcinomas (n = 92). 70% had a low density of ne-tumor cells (< or = 1 cell/mm2). 67% of carcinomas with ne-differentiation showed only single ne-tumor cells, there were small groups in 19% and large groups in 14%. There was an association between higher densities of ne-tumor cells and arrangement in groups. In high malignancy carcinomas we found a higher density of ne-tumor cells and more often an arrangement in groups than in low grade tumors. Our results support reports in literature that ne-differentiation is of prognostic significance.
采用抗嗜铬粒蛋白A单克隆抗体，对102例未经选择和未治疗的前列腺癌进行神经内分泌（NE）分化的免疫组织化学分析。测定NE肿瘤细胞的密度（每平方毫米肿瘤面积中的细胞数）和NE肿瘤细胞的排列方式（单个细胞、小群细胞和大群细胞）。我们在所有癌组织（n = 92）的90%中发现了NE肿瘤细胞。70%的癌组织中NE肿瘤细胞密度较低（≤1个细胞/平方毫米）。67%具有NE分化的癌组织仅显示单个NE肿瘤细胞，19%有小群细胞，14%有大群细胞。NE肿瘤细胞的较高密度与成组排列之间存在关联。在高恶性癌组织中，我们发现NE肿瘤细胞密度更高，且比低级别肿瘤更常出现成组排列。我们的结果支持文献中的报道，即NE分化具有预后意义。
