Kikkawa K, Murata S, Kurosawa H, Toriumi W, Iwasaki H, Nagao T
Pharmacological Research Laboratory, Tanabe Seiyaku Co., Ltd., Saitama, Japan.
J Cardiovasc Pharmacol. 1994 Jan;23(1):166-74. doi: 10.1097/00005344-199401000-00023.
After stroke-prone spontaneously hypertensive rats (SHRSP) received a salt-loaded diet to accelerate onset of stroke, the therapeutic effect of clentiazem, a benzothiazepine Ca antagonist, on neurologic and histologic disorders was examined. Treatment with clentiazem (3, 15, and 30 mg/kg) orally twice daily (b.i.d.) for 28 days after the occurrence of stroke reduced neurologic symptoms and histologic changes of brain and kidney in a dose-dependent manner. Acute treatment with clentiazem (15 mg/kg, b.i.d.) administered immediately after stroke for 1 week not only almost completely abolished neurologic symptoms during treatment, but partially improved them even after treatment. Subacute treatment with clentiazem starting 10 days after stroke and continuing for 18 days also suppressed the neurologic signs. Both acute and subacute treatment improved cerebral histology. These results suggest that clentiazem treatment in the acute and subacute phases of stroke is beneficial.
给易中风自发性高血压大鼠（SHRSP）喂食高盐饮食以加速中风发作后，研究了苯并噻氮䓬类钙拮抗剂克仑硫䓬对神经和组织学紊乱的治疗效果。中风发生后，每天口服两次克仑硫䓬（3、15和30mg/kg），持续28天，可剂量依赖性地减轻大脑和肾脏的神经症状及组织学变化。中风后立即急性给予克仑硫䓬（15mg/kg，每日两次），持续1周，不仅在治疗期间几乎完全消除了神经症状，甚至在治疗后也部分改善了这些症状。中风后10天开始并持续18天的克仑硫䓬亚急性治疗也抑制了神经体征。急性和亚急性治疗均改善了脑组织学。这些结果表明，在中风的急性和亚急性期进行克仑硫䓬治疗是有益的。
