Ellis Y, Davies J A
Department of Pharmacology and Therapeutics, University of Wales College of Medicine, Cardiff, UK.
Neuropeptides. 1994 Jan;26(1):65-9. doi: 10.1016/0143-4179(94)90095-7.
Neuropeptide Y (NPY), peptide YY (PYY), and galanin are found throughout the central nervous system with appreciable levels occurring in the striatum. In this study we have investigated the effects of these peptides on the potassium-stimulated release of endogenous neurotransmitter amino acids from slices of rat striatum. The release of glutamate was significantly reduced by nanomolar concentrations of each peptide, whilst the release of aspartate, gamma-aminobutyric acid (GABA) and glycine was not affected. The reduction in release due to galanin (200 nM) was inhibited by glibenclamide (5 microM). These results support the view that NPY, PYY and galanin modulate neurotransmitter release possibly by a presynaptic action. The results with glibenclamide suggest that the action of galanin is mediated through an ATP-sensitive potassium channel.
神经肽Y（NPY）、肽YY（PYY）和甘丙肽遍布中枢神经系统，纹状体中含量可观。在本研究中，我们研究了这些肽对大鼠纹状体切片中钾离子刺激的内源性神经递质氨基酸释放的影响。每种肽的纳摩尔浓度均可显著降低谷氨酸的释放，而天冬氨酸、γ-氨基丁酸（GABA）和甘氨酸的释放不受影响。甘丙肽（200 nM）引起的释放减少被格列本脲（5 microM）抑制。这些结果支持以下观点：NPY、PYY和甘丙肽可能通过突触前作用调节神经递质释放。格列本脲的结果表明，甘丙肽的作用是通过ATP敏感性钾通道介导的。
