Kronin V V, Anosova N G, Brondz B D, Chernysheva A D, Krivoshein Y S, Popov I A
Crimean Medical Institute, Ministry of Public Health of Ukraine, Simferopol.
Mikrobiol Z. 1993 Sep-Oct;55(5):51-5.
Induction of alloantigen-specific cytotoxic and suppressor activities of lymphocytes was studied upon intravenous immunization of recipients C57Bl/6 with B6.C-H-2bm12 donor's splenocytes irradiated with 2000 rads and introduced in a dose of 9 x 10(7). A possibility was shown to induce a specific cytotoxic and suppressor activities may be induced individually. We studied a possibility to detect the suppressor activity of immune splenocytes in the reaction of skin graft rejection. No significant prolongation of the B6.C-H-2bm12 skin graft life was noted in C57Bl/6 recipients, irradiated with 2000 rads, under the action of adoptive transfer of the immune syngenic splenocytes in comparison with the grafts life in recipients received the adoptive transfer of intact splenocytes.
在用2000拉德照射并以9×10⁷的剂量输入的B6.C-H-2bm12供体脾细胞对C57Bl/6受体进行静脉免疫后，研究了淋巴细胞同种抗原特异性细胞毒性和抑制活性的诱导情况。结果表明，有可能单独诱导出特异性细胞毒性和抑制活性。我们研究了在皮肤移植排斥反应中检测免疫脾细胞抑制活性的可能性。与接受完整脾细胞过继转移的受体中的移植皮肤存活时间相比，在接受免疫同基因脾细胞过继转移作用下，接受2000拉德照射的C57Bl/6受体中，B6.C-H-2bm12皮肤移植的存活时间没有显著延长。
