Fruman D A, Burakoff S J, Bierer B E
Division of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115.
FASEB J. 1994 Apr 1;8(6):391-400. doi: 10.1096/fasebj.8.6.7513288.
Lymphocyte activation requires the transmission of signals from molecules at the plasma membrane to nuclear signals that regulate gene expression. In recent years, several immunosuppressive compounds have been used as probes to identify important and potentially novel molecules involved in lymphocyte signal transduction processes. The immunosuppressants cyclosporin A (CsA), FK506, and rapamycin have been studied in particular detail. Two distinct classes of immunosuppressant binding proteins have been identified, and collectively termed immunophilins. The cyclophilin family of immunophilins binds CsA, whereas the FK506-binding protein (FKBP) family binds FK506 and rapamycin. This review will discuss both the endogenous functions of immunophilins as well as their roles in mediating immunosuppression.
淋巴细胞激活需要信号从质膜分子传递至调节基因表达的核信号。近年来，几种免疫抑制化合物已被用作探针，以识别参与淋巴细胞信号转导过程的重要且可能新颖的分子。免疫抑制剂环孢菌素A（CsA）、FK506和雷帕霉素已得到特别详细的研究。已鉴定出两类不同的免疫抑制剂结合蛋白，统称为亲免素。亲免素的亲环素家族结合CsA，而FK506结合蛋白（FKBP）家族结合FK506和雷帕霉素。本综述将讨论亲免素的内源性功能及其在介导免疫抑制中的作用。
