Kunz J, Hall M N
Department of Biochemistry, University of Basel, Switzerland.
Trends Biochem Sci. 1993 Sep;18(9):334-8. doi: 10.1016/0968-0004(93)90069-y.
The mechanisms of action of the immunosuppressive drugs cyclosporin A (CsA), FK506 and rapamycin are strikingly conserved from yeast to human T cells. Recent results obtained with yeast corroborate calcineurin as the target of CsA-cyclophilin and FK506-FKBP complexes, and reveal a phosphatidylinositol 3-kinase homologue as the target of the rapamycin-FKBP complex.
免疫抑制药物环孢菌素A（CsA）、FK506和雷帕霉素的作用机制从酵母到人类T细胞都有显著的保守性。最近在酵母上获得的结果证实钙调神经磷酸酶是CsA-亲环蛋白和FK506-FKBP复合物的靶点，并揭示磷脂酰肌醇3-激酶同系物是雷帕霉素-FKBP复合物的靶点。
