Fei L, Statters D J, Gill J S, Katritsis D, Camm A J
Department of Cardiological Sciences, St. George's Hospital Medical School, London, England.
Pacing Clin Electrophysiol. 1994 Feb;17(2):199-206. doi: 10.1111/j.1540-8159.1994.tb01372.x.
It has been shown that alterations in QT/RR relationship may be associated arrhythmogenesis in several clinical settings. In the present study the QT/RR relationship was studied in 20 patients with idiopathic ventricular tachycardia (12 men and 8 women, aged 41 +/- 14 years) compared to 20 normal subjects (9 men and 11 women, aged 39 +/- 13 years). All the patients were off any antiarrhythmic drugs and had no evidence of intraventricular conduction defects. The QT intervals and their preceding RR intervals were measured on electrocardiogram strips from 24-hour Holter tapes at hourly intervals. The differences in the maximum, minimum, and mean of either the QT interval or its corrected values between patients with idiopathic ventricular tachycardia and normal subjects were not statistically significant. There was a significant correlation between the QT and RR intervals in normal subjects (gamma = 0.73 +/- 0.12, P < 0.05) and in patients with idiopathic ventricular tachycardia (gamma = 0.80 +/- 0.10, P < 0.05). However, the linear regression line of the QT interval against the RR interval were significantly (P < 0.001) altered in patients with idiopathic ventricular tachycardia (QT = 0.24 +/- 0.18 RR) compared to normal subjects (QT = 0.27 +/- 0.12 RR). We conclude that although there is no significant change in the QT interval and its corrected values, the QT/RR relationship is significantly altered in patients with idiopathic ventricular tachycardia as compared to normal subjects. This may be of importance in the pathogenesis of idiopathic ventricular tachycardia in these patients.
研究表明，在多种临床情况下，QT/RR关系的改变可能与心律失常的发生有关。在本研究中，对20例特发性室性心动过速患者（12例男性，8例女性，年龄41±14岁）与20例正常受试者（9例男性，11例女性，年龄39±13岁）的QT/RR关系进行了研究。所有患者均未服用任何抗心律失常药物，且无室内传导阻滞的证据。每小时从24小时动态心电图记录带上测量QT间期及其前的RR间期。特发性室性心动过速患者与正常受试者之间QT间期或其校正值的最大值、最小值及平均值差异无统计学意义。正常受试者（γ=0.73±0.12，P<0.05）和特发性室性心动过速患者（γ=0.80±0.10，P<0.05）的QT间期与RR间期之间存在显著相关性。然而，与正常受试者（QT=0.27±0.12RR）相比，特发性室性心动过速患者（QT=0.24±0.18RR）的QT间期对RR间期的线性回归线有显著改变（P<0.001）。我们得出结论，尽管QT间期及其校正值无显著变化，但与正常受试者相比，特发性室性心动过速患者的QT/RR关系有显著改变。这可能在这些患者特发性室性心动过速的发病机制中具有重要意义。
