Garland E M, St John M, Asamoto M, Eklund S H, Mattson B J, Johnson L S, Cano M, Cohen S M
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198-3135.
Cancer Lett. 1994 Apr 1;78(1-3):99-107. doi: 10.1016/0304-3835(94)90037-x.
High doses of sodium saccharin (NaSac) increase proliferation in the bladder of the rat, with a male preponderance. The possibility that alpha 2u-globulin is involved in its mechanism of action was evaluated by feeding it at 7.5% of the diet to NCI-Black-Reiter (NBR) male rats, which do not synthesize liver-derived alpha 2u-globulin. NaSac affected urinary parameters similarly in F344 and NBR male rats, but NBR rats consumed more water leading to greater urinary volume. NaSac produced less proliferation in NBR than in intact F344 rats, with intermediate changes in castrated F344 males, which had intermediate urinary alpha 2u-globulin levels.
高剂量糖精钠（NaSac）可增加大鼠膀胱的细胞增殖，且雄性大鼠更为明显。通过将其以7.5%的比例添加到饲料中喂给不合成肝脏来源α2u球蛋白的NCI-黑瑞特（NBR）雄性大鼠，评估α2u球蛋白是否参与其作用机制。NaSac对F344和NBR雄性大鼠的尿液参数影响相似，但NBR大鼠饮水量更多，导致尿量更大。与完整的F344大鼠相比，NaSac在NBR大鼠中引起的细胞增殖较少，去势的F344雄性大鼠有中等程度的变化，其尿液α2u球蛋白水平处于中等。
