Jönsson P, Källén R, Borgström A, Ohlsson K
Department of Surgical Pathophysiology, University of Lund, Malmö General Hospital, Sweden.
Pancreas. 1994 Mar;9(2):244-8. doi: 10.1097/00006676-199403000-00016.
The serum concentrations of immunoreactive pancreatic secretory trypsin inhibitor, cationic elastase, anionic trypsin, cationic trypsin, and total amylase activity, were studied after pancreatic allograft transplantation. Nine patients received whole organ pancreaticoduodenal allografts with exocrine drainage to the bladder. Eight of the patients received simultaneously a renal allograft. The serum concentration of immunoreactive cationic elastase increased gradually during the first postoperative days to a peak on the fifth day after surgery; all other proteins decreased in concentration after the first day. Eighteen episodes of pancreatic and/or kidney rejection, diagnosed by means of kidney biopsy, urinary cytology, kidney function, and urinary amylase levels, were analyzed. The pancreatic proteins displayed different patterns in serum concentration during the days immediately before diagnosis of rejection. The pancreatic secretory trypsin inhibitor showed the most pronounced peak in serum concentration during rejection and even reacted during some episodes without a decline in urinary amylase output. Cationic elastase on the other hand showed no reaction at all. From this homogeneous material it is possible to conclude that changes in serum concentrations during rejection are not the same for all pancreatic exocrine proteins.
在胰腺同种异体移植后，研究了免疫反应性胰腺分泌性胰蛋白酶抑制剂、阳离子弹性蛋白酶、阴离子胰蛋白酶、阳离子胰蛋白酶的血清浓度以及总淀粉酶活性。9例患者接受了全器官胰十二指肠同种异体移植，外分泌液引流至膀胱。其中8例患者同时接受了肾移植。术后第一天，免疫反应性阳离子弹性蛋白酶的血清浓度逐渐升高，在术后第五天达到峰值；术后第一天后，所有其他蛋白质的浓度均下降。通过肾活检、尿细胞学检查、肾功能和尿淀粉酶水平诊断出18次胰腺和/或肾脏排斥反应，并进行了分析。在排斥反应诊断前的几天里，胰腺蛋白的血清浓度呈现出不同的模式。胰腺分泌性胰蛋白酶抑制剂在排斥反应期间血清浓度出现最明显的峰值，甚至在一些尿淀粉酶输出量未下降的情况下也有反应。另一方面，阳离子弹性蛋白酶则完全没有反应。从这种同质材料中可以得出结论，排斥反应期间血清浓度的变化并非所有胰腺外分泌蛋白都相同。
