De Leij L, Helrich W, Stein R, Mattes M J
Department of Clinical Immunology, University Hospital Groningen, The Netherlands.
Int J Cancer Suppl. 1994;8:60-3. doi: 10.1002/ijc.2910570713.
Analysis of the antibodies submitted to the 3 International Workshops on Small Cell Lung Cancer Antigens has resulted in the identification of 15 clusters of antibody reactivity. One of these clusters, named SCLC cluster 2, is characterized by reactivity against an epithelium-associated 38 kDa membrane glycoprotein. SCLC cluster 2, and a number of other antibodies with reportedly similar reactivities, were shown to recognize a protein encoded by the GA733-2 gene, whereas the newly defined SCLC cluster 13 antibodies react with the GA733-1 gene product. We propose to call the antigen detected by SCLC-cluster-2 antibodies "epithelial glycoprotein 2" (EGP-2), and the epithelium-associated glycoprotein recognized by antibodies clustered in SCLC cluster 13 (see elsewhere in this volume) "epithelial glycoprotein 1" (EGP-1). A short overview of the characteristics of both proteins and the applications of anti-EGP-2 antibodies is presented.
对提交给3次小细胞肺癌抗原国际研讨会的抗体进行分析后，已鉴定出15个抗体反应簇。其中一个簇名为小细胞肺癌簇2，其特征是对一种上皮相关的38 kDa膜糖蛋白具有反应性。小细胞肺癌簇2以及一些据报道具有相似反应性的其他抗体，被证明可识别由GA733 - 2基因编码的一种蛋白质，而新定义的小细胞肺癌簇13抗体则与GA733 - 1基因产物发生反应。我们提议将小细胞肺癌簇2抗体检测到的抗原称为“上皮糖蛋白2”（EGP - 2），将在小细胞肺癌簇13中聚集的抗体所识别的上皮相关糖蛋白（见本卷其他地方）称为“上皮糖蛋白1”（EGP - 1）。本文简要概述了这两种蛋白质的特性以及抗EGP - 2抗体的应用。
