[545例慢性丙型肝炎患者干扰素对内分泌及呼吸系统的副作用]

[Side effects of interferon on endocrine and respiratory system in 545 cases of chronic hepatitis C].

作者信息

Okanoue T, Sakamoto S, Yasui K, Takami S, Enjo F, Kashima K, Nakagawa Y, Tada H, Kanaoka H, Ohta M

机构信息

Third Department of Internal Medicine, Kyoto Prefectural University of Medicine.

出版信息

Nihon Shokakibyo Gakkai Zasshi. 1994 May;91(5):995-1002.

PMID:7515124

Abstract

We investigated the side effects of interferon (IFN) on the endocrine and respiratory system in 545 cases of chronic hepatitis C. Eleven of 494 (2.2%) patients with chronic hepatitis C who were treated with natural or recombinant interferon (IFN) developed thyroid disease while on treatment. Eight patients developed hyperthyroidism and 3 patients developed hypothyroidism. All 11 patients required definitive therapy, who became euthyroid after the therapy. Two patients received nIFN alpha and one patient received rIFN alpha 2b developed diabetes mellitus. Two patients received rIFN alpha 2a and rIFN alpha 2b, respectively, developed interstitial pneumonia 12 weeks and 24 weeks later, respectively. One patient showed positive reaction for RA test and LE factor and positive LE cell, and complained of fever, arthralgia and dry cough. These phenomenon disappeared after the cessation of IFN therapy.

摘要

我们调查了545例慢性丙型肝炎患者使用干扰素（IFN）对其内分泌和呼吸系统的副作用。在494例接受天然或重组干扰素（IFN）治疗的慢性丙型肝炎患者中，有11例（2.2%）在治疗期间出现了甲状腺疾病。8例患者出现甲状腺功能亢进，3例患者出现甲状腺功能减退。所有11例患者均需要确定性治疗，治疗后甲状腺功能恢复正常。2例接受天然干扰素α治疗的患者和1例接受重组干扰素α 2b治疗的患者出现了糖尿病。2例分别接受重组干扰素α 2a和重组干扰素α 2b治疗的患者，分别在12周和24周后出现了间质性肺炎。1例类风湿因子（RA）试验、狼疮细胞（LE）因子呈阳性且狼疮细胞阳性的患者，伴有发热、关节痛和干咳。这些现象在停止干扰素治疗后消失。