红细胞同种免疫妊娠中的胎儿淋巴细胞亚群。

Fetal lymphocyte subpopulations in red blood cell iso-immunised pregnancies.

作者信息

Thilaganathan B, Makrydimas G, Plachouras N, Nicolaides K H

机构信息

Harris Birthright Research Centre for Fetal Medicine, King's College Hospital School of Medicine, London, UK.

出版信息

Br J Obstet Gynaecol. 1994 Apr;101(4):315-8. doi: 10.1111/j.1471-0528.1994.tb13617.x.

DOI:10.1111/j.1471-0528.1994.tb13617.x

PMID:7515274

Abstract

OBJECTIVE

To study the association between fetal anaemia and alterations in lymphocyte subpopulations.

DESIGN

Cross-sectional study.

SETTING

The Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, London.

SUBJECTS

Forty-three red blood cell iso-immunised pregnancies undergoing cordocentesis at 19 to 38 weeks gestation.

MAIN OUTCOME MEASURES

Fetal blood haemoglobin concentration, erythroblast count and lymphocyte subpopulations.

RESULTS

The mean T (CD3+), B (CD19+), T-helper (CD4+), T-suppressor/cytotoxic (CD8+) and natural killer (NK: CD16+/CD56+) cell counts in the anaemic fetuses were significantly lower than the appropriate normal mean for gestation (CD3+: t = -3.25, P < 0.01; CD19+: t = -2.14, P < 0.05; CD4+: t -4.03, P < 0.001; CD8+: t = -3.39, P < 0.01 and CD16+/CD56+: t = -3.49, P < 0.01). Furthermore, there was a significant association between the decrease in T lymphocyte number and the degree of fetal anaemia (r = 0.342, P < 0.05).

CONCLUSIONS

Fetuses from red blood cell iso-immunised pregnancies exhibit nonselective lymphopenia that is proportional to the degree of anaemia.

摘要

目的

研究胎儿贫血与淋巴细胞亚群改变之间的关联。

设计

横断面研究。

地点

伦敦国王学院医院医学院哈里斯出生权利胎儿医学研究中心。

研究对象

43例在妊娠19至38周时接受脐带穿刺术的红细胞同种免疫妊娠。

主要观察指标

胎儿血血红蛋白浓度、有核红细胞计数和淋巴细胞亚群。

结果

贫血胎儿的平均T（CD3+）、B（CD19+）、辅助性T细胞（CD4+）、抑制性/细胞毒性T细胞（CD8+）和自然杀伤细胞（NK：CD16+/CD56+）计数显著低于相应孕周的正常平均水平（CD3+：t = -3.25，P < 0.01；CD19+：t = -2.14，P < 0.05；CD4+：t = -4.03，P < 0.001；CD8+：t = -3.39，P < 0.01；CD16+/CD56+：t = -3.49，P < 0.01）。此外，T淋巴细胞数量的减少与胎儿贫血程度之间存在显著关联（r = 0.342，P < 0.05）。