Akaogi K, Sato Y, Ikarashi K, Kawasaki T
Department of Physiology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
Brain Res. 1994 Feb 28;638(1-2):12-20. doi: 10.1016/0006-8993(94)90627-0.
Mossy fiber projections from the brainstem to the nodulus were studied by means of the retrograde transport of horseradish peroxidase (HRP) in the cat. The findings indicate exclusive secondary vestibular projections to the nodulus (96.5% of the total number of labeled cells in cat 1). Major sources of such projections include the caudal half of the medial and inferior vestibular nuclei, and the dorsal half of the superior vestibular nucleus. Groups-x and -z of the vestibular nuclei give rise to minor projections. The projections from groups-f and -y, and the interstitial nucleus of the eighth nerve are very few, if any. Minor extravestibular projections originate from the prepositus hypoglossal nucleus and the infratrigeminal nucleus. All these projections are bilateral. No other nuclei in the brainstem were labeled following HRP injection in the nodulus. No indications of mediolateral and dorsoventral differences in mossy fiber projections were found. There are quantitative differences in the sources of projections to the nodulus, the ventral uvula and the flocculus, all of which belong to the vestibulocerebellum. The largest sources for projections to the nodulus and the ventral uvula are from the vestibular nuclei. Among the vestibular nuclei, group-x provides the major projections to the ventral uvula. For the flocculus, in contrast, the major sources of input are the reticular formation and raphe nuclei. These quantitative differences may play an important role for differential functions of the nodulus, the ventral uvula and the flocculus.
采用辣根过氧化物酶（HRP）逆行转运法，在猫身上研究了从脑干到小结的苔藓纤维投射。研究结果表明，到小结的投射完全是二级前庭投射（猫1中标记细胞总数的96.5%）。这种投射的主要来源包括内侧和下前庭核的后半部分以及上前庭核的背半部分。前庭核的x组和z组产生少量投射。f组和y组以及第八神经间质核的投射极少，即便有也非常少。少量前庭外投射起源于舌下前置核和三叉神经下核。所有这些投射都是双侧性的。在小结注射HRP后，脑干中的其他核均未被标记。未发现苔藓纤维投射存在中外侧和背腹侧差异。到小结、蚓垂腹侧和绒球的投射来源存在数量差异，它们均属于前庭小脑。到小结和蚓垂腹侧的最大投射来源是前庭核。在前庭核中，x组为蚓垂腹侧提供主要投射。相比之下，绒球的主要输入来源是网状结构和中缝核。这些数量差异可能对小结、蚓垂腹侧和绒球的不同功能起着重要作用。
