Nordström P, Samuelsson M, Asberg M, Träskman-Bendz L, Aberg-Wistedt A, Nordin C, Bertilsson L
Department of Clinical Neuroscience, Karolinska Institute, Stockholm.
Suicide Life Threat Behav. 1994 Spring;24(1):1-9.
Suicide risk after attempted suicide, as predicted by cerebrospinal fluid (CSF) monoamine metabolite concentrations, was studied in a sample of 92 psychiatric mood disorder inpatients admitted shortly after attempting suicide. The potential of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) in the CSF to predict suicide risk within the first year after attempted suicide was studied by means of survival analysis after after median split subgrouping. Eleven patients (12%) committed suicide within 1 year after attempted suicide. Eight of these belonged to the below-the-median (< 87 nM) CSF 5-HIAA subgroup, that is, the suicide risk was 17% as compared with 7% among those with above-the-median CSF 5-HIAA. The cumulative number of survived patient-months during the first year after attempted suicide was significantly lower in the low CSF 5-HIAA subgroup. It was concluded that low CSF 5-HIAA predicts short-range suicide risk after attempted suicide in mood disorder psychiatric inpatients. These findings lend further support to the serotonin hypothesis of suicide risk.
在一个由92名自杀未遂后不久入院的精神科情绪障碍住院患者组成的样本中，研究了根据脑脊液（CSF）单胺代谢物浓度预测的自杀未遂后的自杀风险。通过中位数分割亚组后的生存分析，研究了脑脊液中血清素代谢物5-羟吲哚乙酸（5-HIAA）在自杀未遂后第一年内预测自杀风险的潜力。11名患者（12%）在自杀未遂后1年内自杀。其中8名属于脑脊液5-HIAA低于中位数（<87 nM）的亚组，也就是说，自杀风险为17%，而脑脊液5-HIAA高于中位数的患者中这一比例为7%。在自杀未遂后的第一年，脑脊液5-HIAA低亚组中存活的患者月累计数显著更低。得出的结论是，脑脊液5-HIAA水平低可预测情绪障碍精神科住院患者自杀未遂后的短期自杀风险。这些发现进一步支持了自杀风险的血清素假说。
