McCabe N R, Kipiniak M, Kobayashi H, Thirman M, Gill H, Rowley J D, Diaz M O
Department of Pediatrics, University of Chicago, Illinois.
Genes Chromosomes Cancer. 1994 Mar;9(3):221-4. doi: 10.1002/gcc.2870090311.
Translocations involving chromosome band 11q23 are found in both lymphoid and myeloid leukemias as well as in lymphomas, in these translocations. The chromosomes most frequently involved in reciprocal translocations include chromosomes 4, 6, 9, and 19, and we and others have reported that chromosomes 1, 2, 10, 15, 17, 18, 22, and X are also involved. In the cell line Karpas 45, which has a t(X;11) (q13;q23) translocation, we report here that the MLL gene is rearranged and that there are two altered transcripts of MLL that come from the der(11) chromosome.
涉及染色体带11q23的易位在淋巴样和髓样白血病以及淋巴瘤中均有发现。在这些易位中，最常参与相互易位的染色体包括4号、6号、9号和19号染色体，我们和其他人曾报道1号、2号、10号、15号、17号、18号、22号染色体以及X染色体也参与其中。在具有t(X;11)(q13;q23)易位的Karpas 45细胞系中，我们在此报告MLL基因发生了重排，并且有两个来自der(11)染色体的MLL改变转录本。
