Vandevyver C, Stinissen P, Cassiman J J, Raus J
Department of Immunology/Biotechnology, Dr. L. Willems-Instituut at Diepenbeek, Belgium.
J Neuroimmunol. 1994 Jun;52(1):97-9. doi: 10.1016/0165-5728(94)90167-8.
In the present study a tetranucleotide (TGGA)n repeat polymorphism 5' to the myelin basic protein (MBP) gene was evaluated in a group of HLA-class II-typed, chronic progressive multiple sclerosis (MS) patients. This polymorphism has been reported by others to be associated with MS. Contrary to these reports we observed similar allele frequencies in patients and controls. Our results indicate that there is no association between MS and a polymorphism 5' to the MBP gene.
在本研究中，我们对一组已进行HLA-II类分型的慢性进展型多发性硬化症（MS）患者，评估了髓鞘碱性蛋白（MBP）基因5'端的四核苷酸（TGGA）n重复多态性。其他人曾报道该多态性与MS相关。与这些报道相反，我们观察到患者和对照组的等位基因频率相似。我们的结果表明，MS与MBP基因5'端的多态性之间不存在关联。
