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Effectiveness of concomitant setiptiline maleate (Tecipul) on negative symptoms of schizophrenia.

作者信息

Kuniyoshi M, Nakamura J, Miura C, Inanaga K

机构信息

Chikusuikai Hospital, Chikusuikai Institute for Neuroinformation, Yame-city, Japan.

出版信息

Prog Neuropsychopharmacol Biol Psychiatry. 1994 Mar;18(2):339-46. doi: 10.1016/0278-5846(94)90065-5.

DOI:10.1016/0278-5846(94)90065-5
PMID:7516085
Abstract
  1. Setiptiline maleate was administered to schizophrenic patients with the object of improving their negative symptoms. 2. Moderate improvements were observed in 58% of the treated patients, thus usefulness of this drug was demonstrated. 3. There was no aggravation of symptoms, and side effects were minor. 4. Measurements of plasma monoamine metabolites showed a tendency of MHPG to decrease and a significant decrease in 5-HIAA, but no change in the level of HVA was observed, suggesting a relationship between the negative symptoms and noradrenaline and/or serotonin systems.
摘要

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