Beck C, Schmidt C L
Arch Otorhinolaryngol. 1978 Sep 28;221(2):149-52. doi: 10.1007/BF00455886.
During the last 10 years a total of 83 patients with severe cases of unilateral Morbus Menière were treated in our clinic. The proposed therapy was to administer streptomycin (gentamycinsulfate) intratympanically by applying two different ways of procedure. In the first group of 40 patients we attempted to destroy the vestibular organ without harming the cochlea whereby we avoided surgical intervention. In the second group of 43 patients we integrated more recent findings in the pathophysiological mechanism underlying the pathogenesis of Morbus Menière into our therapeutic considerations and attempted to exclusively destroy the secretorial epithelium with minimal dosages of aminoclycoside antibiotics. The results after treatment were clearly better for the second group of patients.
在过去10年里，我们诊所共治疗了83例单侧梅尼埃病重症患者。建议的治疗方法是通过两种不同的操作方式经鼓室内注射链霉素（硫酸庆大霉素）。在第一组40例患者中，我们试图在不损害耳蜗的情况下破坏前庭器官，从而避免手术干预。在第二组43例患者中，我们将梅尼埃病发病机制的病理生理机制的最新研究结果纳入治疗考量，并试图用最小剂量的氨基糖苷类抗生素专门破坏分泌上皮。第二组患者的治疗效果明显更好。
